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Wet Milling Pharmaceuticals

Wet Milling Pharmaceuticals

Celecoxib CLX, a selective COX-2 inhibitor, is a biopharmaceutics classification system BCS class II drug with its bioavailability being limited by thepoor aqueoussolubility. The purpose of this study was to develop and optimize CLX nanocrystallineCLX-NC solid dispersion prepared by the wet medium millingtechnique combined with lyophilizationto enhance oral bioavailability.

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